Brugada Syndrome: Difference between revisions

The '''Brugada syndrome is an hereditary disease that is associated with higher risk of sudden cardiac death'''. It is characterized by typical ECG abnormalities: '''ST segment elevation in the precordial leads (V1 - V3)'''.

*[[w:Autosomal_dominant|autosomal dominant]] inheritance. If one of both parents are affected, their children have a 50% chance of inheriting the disease.

*Man are more often symptomatic than women, probably by the influence of sex hormones on cardiac arrhythmias.  

The Brugada brothers were the first to describe the characteristic ECG findings and link them to sudden death. Before that, the characteristic ECG findings, were often mistaken for a [[Right_Ventricle_MI|right ventricle myocardial infarction]] and already in 1953, a publication mentions that the ECG findings were not associated with ischemia as people often expected.<cite>osher</cite>

*Patients who are symptomatic (syncope, ventricular tachycardias or survivors of sudden cardiac death) have a mortality risk of up to 10% per year. In these patients an [[:w:nl:Internal_Cardiac_Defibrillator|ICD]] should be implanted.  

*Some groups advice an electrofysiologic investigation for risk assessment in Brugada patients,<cite>brug2</cite><cite>brug3</cite> but others could not reproduce the predicive value of these tests,<cite>priori</cite><cite>eckhardt</cite> so this is still controversial.

For a full list of the diagnostic criteria, see <cite>Wilde</cite>

==External links==