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| colspan="2" | I. Global or regional dysfunction and structural alterations<sup>∗</sup> | | colspan="2" | I. Global or regional dysfunction and structural alterations<sup>∗</sup> | ||
|- | |- | ||
| colspan="2" | Major | | colspan="2" style="padding-left:12px" | Major | ||
|- | |- | ||
| valign="top" | | | valign="top" style="padding-left:24px" | | ||
* Severe dilatation and reduction of RV ejection fraction with no (or only mild) LV impairment | * Severe dilatation and reduction of RV ejection fraction with no (or only mild) LV impairment | ||
* Localized RV aneurysms (akinetic or dyskinetic areas with diastolic bulging) | * Localized RV aneurysms (akinetic or dyskinetic areas with diastolic bulging) | ||
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* Regional RV akinesia, dyskinesia, or aneurysm | * Regional RV akinesia, dyskinesia, or aneurysm | ||
|- | |- | ||
| colspan="2" | | | colspan="2" style="padding-left:12px" | Minor | ||
|- | |- | ||
| valign="top" | | | valign="top" style="padding-left:24px" | | ||
* Mild global RV dilatation and/or ejection fraction reduction with normal LV | * Mild global RV dilatation and/or ejection fraction reduction with normal LV | ||
* Mild segmental dilatation of the RV | * Mild segmental dilatation of the RV | ||
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| colspan="2" | II. Tissue characterization of wall | | colspan="2" | II. Tissue characterization of wall | ||
|- | |- | ||
| colspan="2" | Major | | colspan="2" style="padding-left:12px" | Major | ||
|- | |- | ||
| valign="top" | | | valign="top" style="padding-left:24px" | | ||
* Fibrofatty replacement of myocardium on endomyocardial biopsy | * Fibrofatty replacement of myocardium on endomyocardial biopsy | ||
| | | | ||
* Residual myocytes <60% by morphometric analysis (or <50% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample, with or without fatty replacement of tissue on endomyocardial biopsy | * Residual myocytes <60% by morphometric analysis (or <50% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample, with or without fatty replacement of tissue on endomyocardial biopsy | ||
|- | |- | ||
| colspan="2" | Minor | | colspan="2" style="padding-left:12px" | Minor | ||
|- | |- | ||
| | | | ||
| valign="top" | | | valign="top" | | ||
* Residual myocytes 60% to 75% by morphometric analysis (or 50% to 65% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample, with or without fatty replacement of tissue on endomyocardial biopsy | * Residual myocytes 60% to 75% by morphometric analysis (or 50% to 65% if estimated), with fibrous replacement of the RV free wall myocardium in ≥1 sample, with or without fatty replacement of tissue on endomyocardial biopsy | ||
|- | |||
| colspan="2" | III. Repolarization abnormalities | |||
|- | |||
| colspan="2" style="padding-left:12px" | Major | |||
|- | |||
| | |||
| | |||
* Inverted T waves in right precordial leads (V<sub>1</sub>, V<sub>2</sub>, and V<sub>3</sub>) or beyond in individuals >14 years of age (in the absence of complete right bundle-branch block QRS ≥120 ms) | |||
|- | |||
| colspan="2" style="padding-left:12px" | Minor | |||
|- | |||
| valign="top" style="padding-left:24px" | | |||
* Inverted T waves in right precordial leads (V<sub>2</sub> and V<sub>3</sub>) (people age >12 years, in absence of right bundle-branch block) | |||
| | |||
* Inverted T waves in leads V<sub>1</sub> and V<sub>2</sub> in individuals >14 years of age (in the absence of complete right bundle-branch block) or in V<sub>4</sub>, V<sub>5</sub>, or V<sub>6</sub> | |||
* Inverted T waves in leads V<sub>1</sub>, V<sub>2</sub>, V<sub>3</sub>, and V<sub>4</sub> in individuals >14 years of age in the presence of complete right bundle-branch block | |||
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