Early Repolarization

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Author(s) Victor Froelicher, MD & Jonas de Jong, MD
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some notes about authorship
Semantic confusion early repolarization.svg

Early Repolarization is a term used classically for ST segment elevation without underlying disease. It probably has nothing to do with actual early repolarization. It is commonly seen in young men. It is important to discern early repolarization from ST segment elevation from other causes such as ischemia. Characteristics of early repolarization are:[1]

  • an upward concave elevation of the RS-T segment with distinct or "embryonic" J waves
  • slurred downstroke of R waves or distinct J points or both
  • RS-T segment elevation commonly encountered in the precordial leads and more distinct in these leads
  • rapid QRS transition in the precordial leads with counterclockwise rotation
  • persistence of these characteristics for many years
  • absence of reciprocal ST depression
  • large symmetrical T waves

Recently early repolarization has also been used to describe late QRS notching or J wave slurring. When defined as such in the inferior leads (II, III en AVF) it has been found to be associated with an increased risk of cardiac death. Before screening for risk of sudden death by these new types of early repolarization can be perfomed a better definition is needed.

Before then, it has to overcome "growing pains" of being mis-named and the failure of Electrocardiographers to deal with R wave downslope phenomena (J waves, notches and slurs) prior to this time. When R wave downslope phenomena are present, we have to clarify the J-point definition as well as specify where end of the QRS complex and beginning of the ST segment occur.

Prior to 2009, ECG waveform definitions and measurement were based on inclusion of the R wave downslope phenomena in the QRS complex per the CSE Measurement Statement but recent studies have not done so.

These stable 12 lead ECG measurment issues have to be resolved if appropriate population studies can be performed to demonstrate that R wave downslope phenomena (Haïssaguerre ECG patterns[2][3]) can be used to predict individuals at risk of sudden cardiac death due to this genetic mutation.

Early Repolarization

Characterization of standard 12 lead ECG abnormalities can be facilitated by considering the portion of the cardiac ventricular myocytes action potential which influences them. This is only helpful for action potential phenomena originating with the initial wave of activation. Their temporal timing is influenced mainly by transmural dispersion from endo to epicardium. This contrasts with late potentials which are due to phase 0 of the action potentials (depolarization) originating from myocardium isolated by fatty tissue (epsilon waves of ARVD) or by fibrosis (cardiomyopathy) experiencing major delays. These can be arrhythmogenic because they compete with the normal pacemakers.

The Different Phases of Repolarization.

Phase 0 depolarization abnormalities that occur with the initial wave of activation include bundle branch blocks, myocardium damage or abnormalities and intraventicular delays. These can be due to electrical disturbances, myocardial hypertrophy, dilatation, damage or infiltrative disease.

Abnormalities of Phase 2 (mid-repolarization) of the action potential (the plateau) result in ST displacement where amplitude differences in the action potential result in ST elevation caused by transmural ischemia, pericarditis and vagal tone differences or result in ST depression caused by endocardial ischemia, fibrosis or electrolyte abnormalities.

Phase 3 (late-repolarization) abnormalities can result in T wave abnormalities with similar causes as ST depression as well as abnormalities of QT length caused by medications, electrolyte disturbances and specific genetic conditions (LQTS, SQTS).

Less understood but recently highlighted are abnormalities of phase 1 (Early Repolarization). These include abnormal action potentials originating in the right ventricle outflow tract (Brugada syndrome) and those originating in the left ventricle (J wave syndromes).

The exciting feature of these abnormalities is their specific genetic associations. Similar to the QT syndromes, relatively few genes appear to be involved contrasting with the genetic complexity of more common conditions such as cardiomyopathies, atherosclerosis and diabetes.

Introduced in the NEJM in 2009 as Early Repolarization, this new ECG pattern and syndrome is more appropriately named after Michel Haïssaguerre[4] who first reported it (as suggested by Viskin JACC, 2009[5]). The ECG pattern consists of J waves, slurs or notches particularly in the inferior leads and the syndrome requires sudden cardiac death (SCD) without cardiac abnormalities, family history and genetic markers.

However, Early repolarization (ER) was already defined for two areas:

  1. In cellular physiology, ER is defined as Phase 1 of the action potential.
  2. In clinical medicine, ER is defined as a resting ECG pattern of ST elevation in the lateral>Inferior leads sometimes accompanied by J waves or slurs on the R wave downslope, occurring particularly in athletic, young male African Americans[3].

The main concern with this pattern was distinguishing it from ischemia and pericarditis.

Naming of this new syndrome with a name previously assigned to other entities has created considerable confusion particularly in the US where physicians have been taught since the 70's to consider "Early Repolarization" a normal variant of ST elevation.

In fact, though this new, rare syndrome may be found to be more prevalent now that it has been discovered, nomenclature and ECG measurement disagreements could result in more harm than good. This is particularly the case since many of the widely used automated ECG machines put out a statement of Early Repolarization based on ST elevation in an otherwise normal ECG.

Prognostic Implications of the Haïssaguerre ECG Patterns

Hopefully, there are markers on the stable, surface ECG of the Haïssaguerre Pattern (ST elevation and end QRS notching and slurring) that occur in community populations and athletes that can predict risk of cardiovascular death and/or the Haïssaguerre Syndrome.

The available prognostic studies have differing results but some suggest that end QRS notching and slurring, particularly when occurring in the inferior leads or accompanied by downward sloping ST segments, have associated risk. The differences in the studies appear to be due to terminology and methodology issues as well as design shortcomings.

A total of 8 prognostic studies are available as on February 2013. These are summarized in the table below.

Prognostic ER Studies
Prevalence Include in Criteria*
Lead Author Year, Journal Population Size Female (%) African Descent (%) Mean age (SD) FU yrs End Points Design Nationality ERP CVD* Hazard Measurement (1mm) Leads J waves /slurs ST elevation
Tikkannen[6] 2009, NEJM 10,864 48 0 44 ± 8 30 CV mortality, arrythmic deaths community based, prospective Finnish 5.8% 2-3x inferior only vis*, 2 contig* Inf*, Lat* yes no
Sinner 2010, PLOS 1,945 51 0 35-54 18.9 CV mortality MONICA, case control, enhanced with deaths* German 13% 2-4X vis, 2 contig Inf, Lat yes no
Uberio[7][8] 2011, Circ 29,281 13 13 55 ±14 7.6 CV mortality clinic based, prospective USA 14% none GE12L* ST0* /vis Inf, Lat yes yes
Haruta 2011, Circ 5,976 56 0 45 24 CV mortality, unexpected deaths atomic bomb survivors Japan 24% none, unexplained deaths only vis, 2 contig Inf, Lat yes yes
Olson 2011, EHJ 15,141 56 27 54 ± 6 17 Sudden Cardiac Death ARIC population based, prospective USA STE 12.3% 1.2x (white females 2x ) GE12L ST0 (J-pt) Ant*, Inf, Lat no yes
Stavrakis[9] 2012, ANEC 825ER, 255controls 1 40 49 ± 12 6.4 all-cause mortality clinic based, case control USA NA NA, 1.5x all cause vis, 2 contig Inf, Lat yes no
Rollin[10] 2012, AJC 1,161 48 0 50 ± 9 14.2 CV mortality MONICA, prospective French 13% 3 to 8x inf and lat vis, 2 contig Inf, Lat yes no*
Hisamatsu[11] 2013, Circ Japan 7,630 59 0 52 ± 4 15 CV mortality National Circ Survey Japan STE* 3.5% 2.5x, anterior leads (>2mm) vis, any lead Ant, Inf, Lat no yes
Key: Include in Criteria = no if not at all or only considered ST slope or level in ECGs with J waves/slurs, CVD = cardiac death, STE = ST elevation only, vis = visual, contig = contiguous, GE12 L = general electric MUSE program, ST0 = ST at zero msec, beginning of ST segment [J-point], Inf = inferior III, aVF, II, Lat = lateral (V456, I, aVL), Ant = anterior (V123)

Clearly the best follow up study and one unlikely to be duplicated is that by Tikkannen et al[6]. This classic study was only limited by non-computerized ECG acquisition; the paper ECG recordings from over 30 years ago (requiring using the adjacent lead criteria for accuracy unlike modern ECG analyses that rely on waveforms averaged over 10 seconds).

Sinner et al. documented an increased hazard ratio of mortality associated with ER, especially in the inferior leads. However, they used a case-cohort design which only considered a subset of their community based population enriched by all those who died resulting in a limited challenge due to the older age of those who died.

A third outcome study, by Haruta et al. concluded that ER was only predictive of unexplained death. Although unexplained death was intended to be a surrogate for cardiac arrest, the main category coded was unexplained accidental death.

A fourth study by Stavrakis et al[9] considered 852 consecutive patients with ST elevation ≥0.1 mV in inferior or lateral leads from the VA ECG system, similar to what we have used, and randomly selected 257 age-matched patients with normal ECGs as controls.[9]

Early repolarization was associated with a modest increased mortality compared to controls (hazard ratio of 1.49), but comparison to controls rather than the total population from the sampling period of those with ER violates the assumptions of the Cox model.

A 5th study was that of Rollins et al[10] with the French participants in the Monica Study. It was a retrospective study of 1,161 southwestern French subjects 35 to 64 years old. This relatively small study without isolating risk to the inferior leads is hard to reconcile with the larger Finnish study. Some of the examples they provide of high risk ECGs puts their conclusions in doubt.

The figure shows where the CSE experts indicated that these measurements be made.

A sixth and seventh studies by Olson et al and Hisamatsu et al[11] were excellent population studies but did not consider R wave downslope phenomena (Haïssaguerre Pattern) but only ST elevation and included the anterior leads. Uberoi et al[7][8] from the Veterans Affairs was one of the largest multi-ethnic population studies and considered R wave downslope phenomena (Haïssaguerre Pattern) as well as ST elevation.

Studies that have used the same population as a study summarized but considered confounders are not listed but worthy of mention is the study of Perez[12] which found a risk in non-African Americans as opposed to African Americans and a Finnish sub-study which found risk isolated to those with downsloping ST depression. Also of mention, is the study of Uberoi demonstrating any risk of R wave downslope phenomena to be dependent on accompanying Q waves and/or T wave inversion.

ECG Measuement Issues

Before the prognostic significance of the Haïssaguerre Pattern can be demonstrated, there must be agreement on what measurments should be made. It appears that for stable ECG patterns with a QRS duration (including an end QRS slur J wave/slur) less than 120 msec, we should follow the CSE Measurement statement (1985)and consider the J point (also known as QRS end, J-junction, ST0[zero msec] or ST beginning) to occur after the R wave downslope notch/slur/or J wave as determined across all 12 leads. And that the measurement baseline be set in an interval immediately preceding QRS onset as per the CSE Measurement statement. Some of the bizarre and dynamic ECGs may require other rules for measurments but for now the CSE statement should be followed.


References

  1. Kambara H and Phillips J. Long-term evaluation of early repolarization syndrome (normal variant RS-T segment elevation). Am J Cardiol. 1976 Aug;38(2):157-6. DOI:10.1016/0002-9149(76)90142-9 | PubMed ID:133604 | HubMed [2]
  2. [24]
  3. [25]
  4. Haïssaguerre M, Derval N, Sacher F, Jesel L, Deisenhofer I, de Roy L, Pasquié JL, Nogami A, Babuty D, Yli-Mayry S, De Chillou C, Scanu P, Mabo P, Matsuo S, Probst V, Le Scouarnec S, Defaye P, Schlaepfer J, Rostock T, Lacroix D, Lamaison D, Lavergne T, Aizawa Y, Englund A, Anselme F, O'Neill M, Hocini M, Lim KT, Knecht S, Veenhuyzen GD, Bordachar P, Chauvin M, Jais P, Coureau G, Chene G, Klein GJ, and Clémenty J. Sudden cardiac arrest associated with early repolarization. N Engl J Med. 2008 May 8;358(19):2016-23. DOI:10.1056/NEJMoa071968 | PubMed ID:18463377 | HubMed [3]
  5. Viskin S. Idiopathic ventricular fibrillation "Le Syndrome d'Haïssaguerre" and the fear of J waves. J Am Coll Cardiol. 2009 Feb 17;53(7):620-622. DOI:10.1016/j.jacc.2008.11.011 | PubMed ID:19215838 | HubMed [1]
  6. Tikkanen JT, Anttonen O, Junttila MJ, Aro AL, Kerola T, Rissanen HA, Reunanen A, and Huikuri HV. Long-term outcome associated with early repolarization on electrocardiography. N Engl J Med. 2009 Dec 24;361(26):2529-37. DOI:10.1056/NEJMoa0907589 | PubMed ID:19917913 | HubMed [4]
  7. Uberoi A, Jain NA, Perez M, Weinkopff A, Ashley E, Hadley D, Turakhia MP, and Froelicher V. Early repolarization in an ambulatory clinical population. Circulation. 2011 Nov 15;124(20):2208-14. DOI:10.1161/CIRCULATIONAHA.111.047191 | PubMed ID:21986288 | HubMed [6]
  8. Uberoi A, Sallam K, Perez M, Jain NA, Ashley E, and Froelicher V. Prognostic implications of Q waves and T-wave inversion associated with early repolarization. Mayo Clin Proc. 2012 Jul;87(7):614-9. DOI:10.1016/j.mayocp.2012.04.009 | PubMed ID:22766081 | HubMed [20]
  9. Stavrakis S, Patel N, Te C, Golwala H, George A, Lozano P, and Lazzara R. Development and validation of a prognostic index for risk stratification of patients with early repolarization. Ann Noninvasive Electrocardiol. 2012 Oct;17(4):361-71. DOI:10.1111/j.1542-474X.2012.00533.x | PubMed ID:23094882 | HubMed [17]
  10. Rollin A, Maury P, Bongard V, Sacher F, Delay M, Duparc A, Mondoly P, Carrié D, Ferrières J, and Ruidavets JB. Prevalence, prognosis, and identification of the malignant form of early repolarization pattern in a population-based study. Am J Cardiol. 2012 Nov 1;110(9):1302-8. DOI:10.1016/j.amjcard.2012.06.033 | PubMed ID:22819431 | HubMed [19]
  11. Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, and NIPPON DATA90 Research Group. Association between J-point elevation and death from coronary artery disease--15-year follow up of the NIPPON DATA90. Circ J. 2013;77(5):1260-6. DOI:10.1253/circj.cj-12-1273 | PubMed ID:23358431 | HubMed [23]
  12. Perez MV, Uberoi A, Jain NA, Ashley E, Turakhia MP, and Froelicher V. The prognostic value of early repolarization with ST-segment elevation in African Americans. Heart Rhythm. 2012 Apr;9(4):558-65. DOI:10.1016/j.hrthm.2011.11.020 | PubMed ID:22094072 | HubMed [22]
  13. Rosso R, Adler A, Halkin A, and Viskin S. Risk of sudden death among young individuals with J waves and early repolarization: putting the evidence into perspective. Heart Rhythm. 2011 Jun;8(6):923-9. DOI:10.1016/j.hrthm.2011.01.037 | PubMed ID:21295159 | HubMed [5]
  14. Perez MV, Friday K, and Froelicher V. Semantic confusion: the case of early repolarization and the J point. Am J Med. 2012 Sep;125(9):843-4. DOI:10.1016/j.amjmed.2011.08.024 | PubMed ID:22340816 | HubMed [7]
  15. Surawicz B and Macfarlane PW. Inappropriate and confusing electrocardiographic terms: J-wave syndromes and early repolarization. J Am Coll Cardiol. 2011 Apr 12;57(15):1584-6. DOI:10.1016/j.jacc.2010.11.040 | PubMed ID:21474037 | HubMed [8]
  16. Macfarlane PW. Age, sex, and the ST amplitude in health and disease. J Electrocardiol. 2001;34 Suppl:235-41. DOI:10.1054/jelc.2001.28906 | PubMed ID:11781962 | HubMed [9]
  17. Bidoggia H, Maciel JP, Capalozza N, Mosca S, Blaksley EJ, Valverde E, Bertran G, Arini P, Biagetti MO, and Quinteiro RA. Sex-dependent electrocardiographic pattern of cardiac repolarization. Am Heart J. 2000 Sep;140(3):430-6. DOI:10.1067/mhj.2000.108510 | PubMed ID:10966541 | HubMed [10]
  18. Surawicz B and Parikh SR. Prevalence of male and female patterns of early ventricular repolarization in the normal ECG of males and females from childhood to old age. J Am Coll Cardiol. 2002 Nov 20;40(10):1870-6. DOI:10.1016/s0735-1097(02)02492-0 | PubMed ID:12446073 | HubMed [11]
  19. OSBORN JJ. Experimental hypothermia; respiratory and blood pH changes in relation to cardiac function. Am J Physiol. 1953 Dec;175(3):389-98. DOI:10.1152/ajplegacy.1953.175.3.389 | PubMed ID:13114420 | HubMed [12]
  20. Kambara H and Phillips J. Long-term evaluation of early repolarization syndrome (normal variant RS-T segment elevation). Am J Cardiol. 1976 Aug;38(2):157-6. DOI:10.1016/0002-9149(76)90142-9 | PubMed ID:133604 | HubMed [13]
  21. Viskin S. Idiopathic ventricular fibrillation "Le Syndrome d'Haïssaguerre" and the fear of J waves. J Am Coll Cardiol. 2009 Feb 17;53(7):620-622. DOI:10.1016/j.jacc.2008.11.011 | PubMed ID:19215838 | HubMed [14]
  22. Cappato R, Furlanello F, Giovinazzo V, Infusino T, Lupo P, Pittalis M, Foresti S, De Ambroggi G, Ali H, Bianco E, Riccamboni R, Butera G, Ricci C, Ranucci M, Pelliccia A, and De Ambroggi L. J wave, QRS slurring, and ST elevation in athletes with cardiac arrest in the absence of heart disease: marker of risk or innocent bystander?. Circ Arrhythm Electrophysiol. 2010 Aug;3(4):305-11. DOI:10.1161/CIRCEP.110.945824 | PubMed ID:20511538 | HubMed [15]
  23. Thygesen K, Alpert JS, White HD, and Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. J Am Coll Cardiol. 2007 Nov 27;50(22):2173-95. DOI:10.1016/j.jacc.2007.09.011 | PubMed ID:18036459 | HubMed [16]
  24. Junttila MJ, Sager SJ, Tikkanen JT, Anttonen O, Huikuri HV, and Myerburg RJ. Clinical significance of variants of J-points and J-waves: early repolarization patterns and risk. Eur Heart J. 2012 Nov;33(21):2639-43. DOI:10.1093/eurheartj/ehs110 | PubMed ID:22645193 | HubMed [18]
  25. Junttila MJ, Sager SJ, Tikkanen JT, Anttonen O, Huikuri HV, and Myerburg RJ. Clinical significance of variants of J-points and J-waves: early repolarization patterns and risk. Eur Heart J. 2012 Nov;33(21):2639-43. DOI:10.1093/eurheartj/ehs110 | PubMed ID:22645193 | HubMed [21]
  26. [26]
  27. [27]
  28. [28]
  29. [29]
  30. [30]
All Medline abstracts: PubMed | HubMed