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Brugada Syndrome: Difference between revisions
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[[Image:Brugada.png|thumb|Typical ECG abnormalities in Brugada syndrome: ST elevation in V1-V3, without ischemia.]] | [[Image:Brugada.png|thumb|Typical ECG abnormalities in Brugada syndrome: ST elevation in V1-V3, without ischemia.]] | ||
[[Image:Brugada_ecg_characteristics. | [[Image:Brugada_ecg_characteristics.svg|thumb| Typical ECG abnormalities in Brugada syndrome]] | ||
[[Image:brugada.jpg|thumb| Dr. Pedro Brugada. Pedro and Josep Brugada described in 1992 a landmark publication with a case-series of 8 patients with sudden cardiac death. <cite>Brugada</cite> Currently, three brothers of the Brugada family (Pedro, Josep and Ramon Brugada) conduct research in the syndrome that has been named after them.]] | [[Image:brugada.jpg|thumb| Dr. Pedro Brugada. Pedro and Josep Brugada described in 1992 a landmark publication with a case-series of 8 patients with sudden cardiac death. <cite>Brugada</cite> Currently, three brothers of the Brugada family (Pedro, Josep and Ramon Brugada) conduct research in the syndrome that has been named after them.]] | ||
[[Image:scn5a.jpg|thumb| The SCN5a gen is located on the short arm (p) of chromosome 3]] | [[Image:scn5a.jpg|thumb| The SCN5a gen is located on the short arm (p) of chromosome 3]] | ||
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Three ECG repolarization patterns in the right precordial leads are recognized in the diagnosis of Brugada syndrome. | Three ECG repolarization patterns in the right precordial leads are recognized in the diagnosis of Brugada syndrome. | ||
'''Type I''' is the only ECG criterion that is diagnostic of Brugada syndrome. The type I ECG is characterized by a J elevation >=2 mm (0.2 mV) a | '''Type I''' is the only ECG criterion that is diagnostic of Brugada syndrome. The type I ECG is characterized by a J elevation >=2 mm (0.2 mV) a coved type ST segment followed by a negative T wave (see figure). Brugada syndrome is definitively diagnosed when a type 1 ST-segment is observed in >1 right precordial lead (V1 to V3) in the presence or absence of a sodium channel–blocking agent, and in conjunction with one of the following: | ||
*documented ventricular fibrillation (VF) | *documented ventricular fibrillation (VF) | ||
*polymorphic ventricular tachycardia (VT) | *polymorphic ventricular tachycardia (VT) | ||
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*[http://www.genereviews.org/servlet/access?id=8888891&key=ghdBRjkdNXE6y&gry=INSERTGRY&fcn=y&fw=E0gK&filename=/profiles/brugada/index.html Genereview Brugada] | *[http://www.genereviews.org/servlet/access?id=8888891&key=ghdBRjkdNXE6y&gry=INSERTGRY&fcn=y&fw=E0gK&filename=/profiles/brugada/index.html Genereview Brugada] | ||
*[http://www.brugadadrugs.org Brugada drugs contains lists of medications that should be avoided in patients with Brugada syndrome and medication that can be used to diagnose the syndrome] | *[http://www.brugadadrugs.org Brugada drugs contains lists of medications that should be avoided in patients with Brugada syndrome and medication that can be used to diagnose the syndrome] | ||
==References== | |||
== | |||
<biblio> | <biblio> | ||
#Wilde pmid=15898165 | #Wilde pmid=15898165 | ||
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#brug3 pmid=12776858 | #brug3 pmid=12776858 | ||
#priori pmid=11901046 | #priori pmid=11901046 | ||
#Wilde2 pmid=12417552 | #Wilde2 pmid=12417552 | ||
#Morita pmid=18838563 | #Morita pmid=18838563 | ||
#eckhardt pmid=15642768 | |||
</biblio> | </biblio> | ||