Basics

Author(s)	I.A.C. van der Bilt, MD
Moderator	I.A.C. van der Bilt, MD
Supervisor
some notes about authorship

How do I begin to read an ECG?

A short ECG registration of normal heart rhythm (sinus rhythm)

An example of a normal ECG. Click on the Image for an enlargement

Click on the ECG to see an enlargement. Where do you start when interpreting an ECG?

• on the top left are the patient's information, name, sex and date of birth
• at the right of that are below each other the Frequency, the conduction times (PQ,QRS,QT/QTc), and the heart axis (P-top axis, QRS axis and T-top axis)
• further to the right is the interpretation of the ECG written (this often misses in a 'fresh' ECG, but later the interpretation of the cardiologist or computer will be added)
• down left is the 'paper speed' (25 mm/s on the horizontal axis), the sensitivity (10mm/mV) and the filter's frequency (40Hz, filters noise from eg. lights)
• finally there is a calibration on the ECG, on the beginning of every lead is a vertical block that shows with what amplitude a 1 mV signal is drawn. So the height and depth of these signals are a measurement for the voltage. If this is not the set at 10 mm, there is something wrong with the machine setting.
• further we have the ECG leads themselves of course, these will be discussed below.

Note that the lay-out is different for every machine, but most machines will show the information above somewhere.

What does the ECG register?

An ECG is a registration of the heart's electric activity.

Just like skeletal muscles, the heart is electrically stimulated to contract. This stimulation is also called activation or excitation. Cardiac muscles are electrically charged at rest. The inside of the cell is negatively charged relative to the outside (resting potential). If the cardiac muscle cells are electrically stimulated they depolarize (the resting potential changes from negative to positive) and contract. As the impulse spreads through the heart, the electric field changes continually in size and direction. The ECG is a graphical visualisation of these electric signals in the heart.

The ECG represents the sum of the action potentials of millions of cardiomyocytes

width=382|height=315|quality=best|align=right	</flash>
This movie shows the contraction of a single (rabbit) heart cell. The glass electrode measures the electrical current in the heart cell (with thepatch-clamp method). The electrical signal is written in blue and shows the actionpotential. Courtesy of Arie Verkerk and Antoni van Ginneken, AMC, Amsterdam, The Netherlands.

The heart consists of approximately 300 trillion cells

In rest the heart cells are negatively charged. Through the depolarization by surrounding cells they become positively charged and they contract.

During the depolarization sodium-ions stream inwards the cell. Subsequently the calcium-ions stream into the cell. These calcium-ions give the actual muscular contraction. Finally the potassium-ions stream out of the cell. During the repolarisation the ion concentration is corrected. On the ECG, an action potential wave coming towards the electrode is shown as a positive (upwards) signal. Here the ECG electrode is represented as an eye.

The individual action potentials of the individual cardiomyocytes are averaged. The final result which is shown on the ECG is actually the average of trillions of microscopic electronical signals.

The electric discharge of the heart

The electric discharge of the heart, first slowly

The electric discharge of the heart, faster now

The sinal node (SA node) contains pacemakercells which determine the heart frequency. First the atria depolarise and contract, after that the ventricles The electrical signal between the atria and the ventricles goes from the sinus node, via the atria to the AV-node (atrioventricular transition) to the His bundle and subsequently to the right and left bundle branch, which end in a dense network of Purkinje fibers.

The different ECG waves

The origin of the different waves on the ECG

The QRS complex is formed by the sum of the electric avtivity of the inner (endocardial) and the outer (epicardial) cardiomyocytes

Example of the different QRS configuations

The P wave is the result of the atrial depolarization. This depolarization starts in the SA (sino-atrial) node. The signal produces by pacemakercells in the SA node is conducted by the conduction system to the right and left atria. Normal atrial repolarisation is not visible on the ECG (but can be visible during atrial infarction and pericarditis).

The QRS complex is the average of the depolarization waves of the inner (endocardial) and outer (epicardial) cardiomyocytes. As the endocardial cardiomyocytes depolarize slightly earlier than the outer layers, a typical QRS pattern occurs (figure).

The T wave represents the repolarisation of the ventricles. There is no cardiac muscle activity during the T wave.

One heart beat consists of an atrial depolarization --> atrial contraction --> p-wave, ventricular depolarization --> ventricular contraction --> ORS-complex and the resting phase (including the repolarization during the T-wave) between two heart beats.

Have a look at this excellent [animation of the heart cycle]

The origin of the U wave is unknown. This wave possibly results from "afterdepolarizations" of the ventricles.

The letters "Q", "R" and "S" are used to describe the QRS complex:

• Q: the first negative deflection after the p-wave. If the first deflection is not negative, the Q is absent.
• R: the positive deflection
• S: the negative deflection after the R-wave

• small print letters (q, r, s) are used to describe deflections of small amplitude. For example: qRS = small q, tall R, deep S.
• R`: is used to describe a second R-wave (as in a [[right bundlebranch block])

See figure for some examples of this.

The history of the ECG

Willem Einthoven (1860-1927), the founder of the current ECG

ECG from Eindhoven's first publication. Pfügers Archiv March 1895, page 101-123

Einthoven's string-galvanometer, now in the Science Museum in Londen. The patient had to put his hands in salt baths to which the electrodes were connected. Image from the IEEE history society.

The last generation of ECG equipment. Image courtesy of General Electric

The history of the ECG goes back more than one and a half century

In 1843 Emil Du Bois-Reymond, a german physiologist, was the firt to describe "action potentials" of muscular contraction. He used a highly sensitive galvanometer, which contained more than 5 km of wire. Du Bios Reymond named the different waves: "o" was the stable equilibrium and he was the first to use the p, q, r and s to describe the different waves. [1]

In 1850 M. Hoffa described how he could induce irregular contractions of the ventricles of doghearts by administering electrical shock. [2]

In 1887 the English physiologist Augustus D. Waller from Londen published the first human electrocardiogram. He used a capillar-electrometer. [3]

The dutchman Willem Einthoven (1860-1927) introduced in 1893 the term 'electrocardiogram'. He described in 1895 how he used a galvanometer to visualize the electrical activity of the heart. In 1924 he received the Nobelprize for his work on the ECG. He connected electrodes to a patienta showed the electrical difference between two electrodes on the galvanometer. We still now use the term: Einthovens'leads. The string galvanometer (see Image) was the first clinical instrument on the recording of an ECG.

In 1905 Einthoven recorded the first 'telecardiogram' from the hospital to his laboratoy 1.5 km away.

In 1906 Einthoven published the first article in which he described a series of abnormal ECGs: left- and right bundlebranchblock, left- and right atrialdilatation, the U wave, notching of the QRS complex, ventricular extrasystoles, bigemini, atrialflutter and total AV block. [4]

The ECG electrodes

click on the Image for an enlargement

Electric activity going through the heart, can be measured by external (skin)electrodes. The electrocardiogram (ECG) registers these activities from these electrodes which have been attached on diffrent places on the body. In total, twelve leads are calculated using ten electrodes.

The ten electrodes are:

• the extremity leads:
  • LA - left arm
  • RA - right arm
  • N - neutral, on the right leg (= electrisch aarde of nulpunt ten opzichte waarvan de electrische spanning wordt gemeten)
  • F - foot, on the left leg

It makes no difference whether the electrodes are attached proximal or distal on the extremities. However, it is best to be uniform in this. (eg. do not attach an electrode on the left shoulder and one on the right wrist).

• the chest leads:
  • V1 - placed in the 4th intercostal space, right of the sternum
  • V2 - placed in the 4th intercostal space, left of the sternum
  • V3 - placed between V2 and V4
  • V4 - placed 5th intercostal space in the nippleline
  • V5 - placed between V4 ann V6
  • V6 - placed in the axillar line on the same height as V4

Using these 10 electrodes, 12 leads can be derived. There are 6 extremity leads and 6 precordial leads.

The Extremity Leads

The extremity leads are:

• I from the right ot the left arm
• II from the right arm to the left leg
• III from the left arm to the left leg

An easy rule to remember: lead I + lead III = lead II This is doen with the use of the height or depth, independent of the wave (QRS, P of T). Example: if in lead I, the QrS complex is 3 mm in height and in lead III 9mm, the height of the QRS-complex in lead II is 12mm.

Other exttremity leads are:

• AVL points to the left arm
• AVR points to the right arm
• AVF points to the feet

The capital A stands for "augmented" and V for "voltage".

(aVR + aVL + aVF = 0)

The Chest Leads

The precordial, or chestleads, (V1,V2,V3,V4,V5 and V6) 'observe' the depolarization wave in the frontal plane

Example: V1 is close to the right ventricle and the right atrium. Signals in these areas of the heart have the largest signal in this lead. V6 isthe closest to the laterale wall of the left ventricle.

Special leads

In case of an inferior wall infarct, extra leads may be used:

1. In a right side ECG, V1 and V2 remain on the same place.V3 to V6 are placed on the same place but mirrored on the chest. So V4 is in the middle of the right clavicle. On the ECG it should be marked that it is a Right sided ECG. V4R (V4 but right sided) is a sensitive lead to diagnose right ventricular infarction.
2. Leads V7-V8-V9 can be used to diagnose a posteriorinfarct. It is means that after V6, leads are pkaced towards the back. See the chapterIschemia for other ways of diagnosing posterior infarction.

Technical Problems

References

1. Du Bois-Reymond, E. Untersuchungen uber thierische Elektricitat. Reimer, Berlin: 1848.

2. Hoffa M, Ludwig C. 1850. Einige neue versuche uber herzbewegung. Zeitschrift Rationelle Medizin, 9: 107-144

3. Waller AD. A demonstration on man of electromotive changes accompanying the heart's beat. J Physiol (London) 1887;8:229-234

4. Einthoven W. Le telecardiogramme. Arch Int de Physiol 1906;4:132-164

5. Einthoven W. Über die Form des menschlichen Electrocardiogramms. Pfügers Archiv maart 1895, pagina 101-123

6. Marey EJ. Des variations electriques des muscles et du couer en particulier etudies au moyen de l'electrometre de M Lippman. Compres Rendus Hebdomadaires des Seances de l'Acadamie des sciences 1876;82:975-977

7. Márquez MF, Colín L, Guevara M, Iturralde P, and Hermosillo AG. Common electrocardiographic artifacts mimicking arrhythmias in ambulatory monitoring. Am Heart J. 2002 Aug;144(2):187-97. DOI:10.1067/mhj.2002.124047 |

External links

• An extensive history of the ECG