Conduction

«Step 2: Rate

Step 4: Learn how to determine the heart's conduction axis»

Author(s)	J.S.S.G. de Jong, MD
Moderator	J.S.S.G. de Jong
Supervisor
some notes about authorship

The PQ interval

The PQ duration depends on the conduction velocity in the atria, AV node, His bundle, bundle branches and Purkinje fibers

The PQ interval starts at the beginning of the atrial contraction and ends at the beginning of the ventricular contraction.

The PQ interval (sometimes referred to as the PR interval as a Q wave is not always present) indicates how fast the action potential is transmitted through the AV node (atrioventricular) from the atria to the ventricles. Measurement should start at the beginning of the P wave and end at the beginning of the QRS segment.

The normal PQ interval is between 0.12 and 0.20 seconds.

A prolonged PQ interval is a sign of a degradation of the conduction system or increased vagal tone (Bezold-Jarisch reflex), or it can be pharmacologically induced.

This is called 1st, 2nd or 3rd degree AV block.

A short PQ interval can be seen in the WPW syndrome in which faster-than-normal conduction exists between the atria and the ventricles.

The QRS duration

The QRS duration indicates how fast the ventricles depolarize. The normal QRS is < 0.10 seconds

The ventricles depolarize normally within 0.10 seconds. When this is longer than 110 miliseconds[1], this is a conduction delay. Possible causes of a QRS duration > 110 miliseconds include:

• Left bundle branch block
• Right bundle branch block
• Electrolyte Disorders
• Idioventricular rhythm and paced rhythm

For the diagnosis of LBBB or RBBB QRS duration must be >120 ms.

The QT interval

The QT interval starts at the onset of the Q wave and ends where the tangent line for the steepest part of the T wave intersects with the baseline of the ECG.

The eyeballing method to estimate QT prolongation. If the QT interval ends before the imaginary boundary halfway two QRS complexes, the QTc is probably normal. If the QTc reaches beyond the halfway line, the QTc is probably prolonged. This method is only 'valid' in registrations with normal (60-100/min) heart rates.

The normal QTc (corrected) interval The QT interval indicates how fast the ventricles are repolarized, becoming ready for a new cycle.

The normal value for QTc is: below 450ms for men and below 460ms for women as agreed upon by the ACC / ESC. [2]

In a recent ACC consensus document an expert writing group suggest that in a hospital setting the upper limit be raised to the 99th percentile of normal: 470ms in males and 480 ms in females, as approximately 10% to 20% of the general population have a QTc > 440m s. For both men and women QTc > 500ms is considered highly abnormal.[3]

If QTc is < 340ms short QT syndrome can be considered.

The QT interval comprises the QRS-complex, the ST-segment, and the T-wave. One difficultly of QT interpretation is that the QT interval gets shorter as the heart rate increases. This problem can be solved by correcting the QT time for heart rate using the Bazett formula:

Thus at a heart rate of 60 bpm, the RR interval is 1 second and the QTc equals QT/1. The QTc calculator can be used to easily calculate QTc from the QT and the heart rate or RR interval.

On modern ECG machines, the QTc is given. However, the machines are not always capable of making the correct determination of the end of the T wave. Therefore, it is important to check the QT time manually.

Alternatives to the Bazzett correction formula are the Fridericia, Framingham and Hodges formulas. The latter two perform better at high heart rates (>100 /min). [4][5] Fridericia: QTc = QT{HR/60}1/3, Framingham: QTc = QT + 0.154{1 – (60/HR)}, Hodges: QTc = QT + 1.75 (heart rate - 60).

Dr Surawicz, founder of the tangent method, still active in November 2006, at age 89.

Although QT prolongation is potentially lethal, measurement of the QT interval by physicians is not standardized, since different definitions of the end of the T wave exist.[6] Most QT experts define the end of the T wave as the intersection of the steepest tangent line from the end of the T-wave with the base line of the ECG.[7] This leads to the following stepwise approach:

Stepwise approach to correct measurement of the QT interval

Use lead II. Use lead V5 alternatively if lead II cannot be read. Draw a line through the baseline (preferably the PR segment) Draw a tangent against the steepest part of the end of the T wave. If the T wave has two positive deflections, the taller deflection should be chosen. If the T wave is biphasic, the end of the taller deflection should be chosen. The QT interval starts at the beginning of the QRS interval and ends where the tangent and baseline cross. If the QRS duration exceeds 120ms the amount surpassing 120ms should be deducted from the QT interval (i.e. QT=QT-(QRS width-120ms) ) Calculate QTc according to Bazett: . You can use the QTc calculator for this.

In a pathological prolonged QT time, it takes longer than the normal amount of time for the myocardial cells to be ready for a new cycle. There is a possibility that some cells are not yet repolarized, but that a new cycle is already initiated. These cells are at risk for uncontrolled depolarization, induction of Torsade de Pointes and subsequent Ventricular Fibrillation.

Causes of QT prolongation
The QT interval is prolonged in congenital long QT syndrome, but QT prolongation can also occur be acquire as a results of: Medication (anti-arrhythmics, tricyclic antidepressants, phenothiazedes, for a complete list see Torsades.org Electrolyte imbalances Ischemia. QT prolongation is often treated with beta blockers.

If the QT segment is abnormal, it can be difficult to define the end of the T wave. Below are a number of examples that suggest how QT should be measured in these patients.

How to measure QT if the QT segement is abnormal
The T wave is broad, but the tangent crosses the baseline before the T wave joins the baseline. The QT interval would be overestimated when this last definition of the end of the T wave would be used.	The ECG does not meet the baseline after the end of the T wave. Still, the crossing of the tangent and baseline should be used for measurements.	A bifasic T wave. The tangent to the 'hump' with the largest amplitude is chosen. This can change from beat to beat, making it more important to average several measurements.

References

1. Surawicz B, Childers R, Deal BJ, Gettes LS, Bailey JJ, Gorgels A, Hancock EW, Josephson M, Kligfield P, Kors JA, Macfarlane P, Mason JW, Mirvis DM, Okin P, Pahlm O, Rautaharju PM, van Herpen G, Wagner GS, Wellens H, American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology, American College of Cardiology Foundation, and Heart Rhythm Society. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009 Mar 17;119(10):e235-40. DOI:10.1161/CIRCULATIONAHA.108.191095 |
2. Rautaharju PM, Surawicz B, Gettes LS, Bailey JJ, Childers R, Deal BJ, Gorgels A, Hancock EW, Josephson M, Kligfield P, Kors JA, Macfarlane P, Mason JW, Mirvis DM, Okin P, Pahlm O, van Herpen G, Wagner GS, Wellens H, American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology, American College of Cardiology Foundation, and Heart Rhythm Society. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009 Mar 17;119(10):e241-50. DOI:10.1161/CIRCULATIONAHA.108.191096 |
3. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, Council on Cardiovascular Nursing, and American College of Cardiology Foundation. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010 Mar 2;55(9):934-47. DOI:10.1016/j.jacc.2010.01.001 |
4. Indik JH, Pearson EC, Fried K, and Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm. 2006 Sep;3(9):1003-7. DOI:10.1016/j.hrthm.2006.05.023 |
5. Dogan A, Tunc E, Varol E, Ozaydin M, and Ozturk M. Comparison of the four formulas of adjusting QT interval for the heart rate in the middle-aged healthy Turkish men. Ann Noninvasive Electrocardiol. 2005 Apr;10(2):134-41. DOI:10.1111/j.1542-474X.2005.05604.x |
6. Viskin S, Rosovski U, Sands AJ, Chen E, Kistler PM, Kalman JM, Rodriguez Chavez L, Iturralde Torres P, Cruz F FE, Centurión OA, Fujiki A, Maury P, Chen X, Krahn AD, Roithinger F, Zhang L, Vincent GM, and Zeltser D. Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one. Heart Rhythm. 2005 Jun;2(6):569-74. DOI:10.1016/j.hrthm.2005.02.011 |
7. LEPESCHKIN E and SURAWICZ B. The measurement of the Q-T interval of the electrocardiogram. Circulation. 1952 Sep;6(3):378-88. DOI:10.1161/01.cir.6.3.378 |

8. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1920;7:353-370.

9. Gaita F, Giustetto C, Bianchi F, Wolpert C, Schimpf R, Riccardi R, Grossi S, Richiardi E, and Borggrefe M. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003 Aug 26;108(8):965-70. DOI:10.1161/01.CIR.0000085071.28695.C4 |
10. Moss AJ. Measurement of the QT interval and the risk associated with QTc interval prolongation: a review. Am J Cardiol. 1993 Aug 26;72(6):23B-25B. DOI:10.1016/0002-9149(93)90036-c |