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During ventricular pacing this method overestimates the QTc. The Framingham formula performs better during pacing, but still overestimates the QTc in sinus rhthm by about 37-43 msec.<cite>Chiladakis</cite>
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During ventricular pacing this method overestimates the QTc. The Framingham formula performs better during pacing, but still overestimates the QTc in sinus rhythm (in the same patient) by about 37-43 msec.<cite>Chiladakis</cite>
    
In a pathological prolonged QT time, it takes longer than the normal amount of time for the myocardial cells to be ready for a new cycle. There is a possibility that some cells are not yet repolarized, but that a new cycle is already initiated. These cells are at risk for uncontrolled depolarization, induction of  [[Torsade de Pointes]] and subsequent [[Ventricular Fibrillation]].
 
In a pathological prolonged QT time, it takes longer than the normal amount of time for the myocardial cells to be ready for a new cycle. There is a possibility that some cells are not yet repolarized, but that a new cycle is already initiated. These cells are at risk for uncontrolled depolarization, induction of  [[Torsade de Pointes]] and subsequent [[Ventricular Fibrillation]].

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