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Arrhythmogenic Right Ventricular Cardiomyopathy: Difference between revisions
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Arrhythmogenic Right Ventricular Cardiomyopathy (view source)
Revision as of 05:12, 13 April 2010
, 13 April 2010→Table 1
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| colspan="2" style="padding-left:12px" | Major | | colspan="2" style="padding-left:12px" | Major | ||
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* Epsilon waves or localized prolongation (>110 ms) of the QRS complex in right precordial leads (V<sub>1</sub> to V<sub>3</sub>) | * Epsilon waves or localized prolongation (>110 ms) of the QRS complex in right precordial leads (V<sub>1</sub> to V<sub>3</sub>) | ||
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| colspan="2" style="padding-left:12px" | Minor | | colspan="2" style="padding-left:12px" | Minor | ||
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* Late potentials (SAECG) | * Late potentials (SAECG) | ||
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| colspan="2" style="padding-left:12px" | Minor | | colspan="2" style="padding-left:12px" | Minor | ||
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* Left bundle-branch block–type ventricular tachycardia (sustained and nonsustained) (ECG, Holter, exercise) | * Left bundle-branch block–type ventricular tachycardia (sustained and nonsustained) (ECG, Holter, exercise) | ||
* Frequent ventricular extrasystoles (>1000 per 24 hours) (Holter) | * Frequent ventricular extrasystoles (>1000 per 24 hours) (Holter) | ||
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* Nonsustained or sustained ventricular tachycardia of RV outflow configuration, left bundle-branch block morphology with inferior axis (positive QRS in leads II, III, and aVF and negative in lead aVL) or of unknown axis | * Nonsustained or sustained ventricular tachycardia of RV outflow configuration, left bundle-branch block morphology with inferior axis (positive QRS in leads II, III, and aVF and negative in lead aVL) or of unknown axis | ||
* >500 ventricular extrasystoles per 24 hours (Holter) | * >500 ventricular extrasystoles per 24 hours (Holter) | ||
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| colspan="2" | VI. Family history | |||
|- | |||
| colspan="2" style="padding-left:12px" | Major | |||
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| style="padding-left:24px" valign="top" | | |||
* Familial disease confirmed at necropsy or surgery | |||
| | |||
* ARVC/D confirmed in a first-degree relative who meets current Task Force criteria | |||
* ARVC/D confirmed pathologically at autopsy or surgery in a first-degree relative | |||
* Identification of a pathogenic mutation<sup>†</sup> categorized as associated or probably associated with ARVC/D in the patient under evaluation | |||
|- | |||
| colspan="2" style="padding-left:12px" | Minor | |||
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| style="padding-left:24px" valign="top" | | |||
* Family history of premature sudden death (<35 years of age) due to suspected ARVC/D | |||
* Familial history (clinical diagnosis based on present criteria) | |||
| | |||
* History of ARVC/D in a first-degree relative in whom it is not possible or practical to determine whether the family member meets current Task Force criteria | |||
* Premature sudden death (<35 years of age) due to suspected ARVC/D in a first-degree relative | |||
* ARVC/D confirmed pathologically or by current Task Force Criteria in second-degree relative | |||
|- | |||
| colspan="2" | | |||
<ul> | |||
<li>PLAX indicates parasternal long-axis view; RVOT, RV outflow tract; BSA, body surface area; PSAX, parasternal short-axis view; aVF, augmented voltage unipolar left foot lead; and aVL, augmented voltage unipolar left arm lead.</li> | |||
<li>Diagnostic terminology for original criteria: This diagnosis is fulfilled by the presence of 2 major, or 1 major plus 2 minor criteria or 4 minor criteria from different groups. Diagnostic terminology for revised criteria: definite diagnosis: 2 major or 1 major and 2 minor criteria or 4 minor from different categories; borderline: 1 major and 1 minor or 3 minor criteria from different categories; possible: 1 major or 2 minor criteria from different categories.</li> | |||
<li><sup>∗</sup> Hypokinesis is not included in this or subsequent definitions of RV regional wall motion abnormalities for the proposed modified criteria.</li> | |||
<li><sup>†</sup> A pathogenic mutation is a DNA alteration associated with ARVC/D that alters or is expected to alter the encoded protein, is unobserved or rare in a large non–ARVC/D control population, and either alters or is predicted to alter the structure or function of the protein or has demonstrated linkage to the disease phenotype in a conclusive pedigree.</li> | |||
</ul> | |||
|} | |} | ||