Brugada Syndrome: Difference between revisions
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The '''Brugada syndrome is an hereditary disease that is associated with higher risk of sudden cardiac death'''. It is characterized by typical ECG abnormalities: '''ST segment elevation in the precordial leads (V1 - V3)'''. | The '''Brugada syndrome is an hereditary disease that is associated with higher risk of sudden cardiac death'''. It is characterized by typical ECG abnormalities: '''ST segment elevation in the precordial leads (V1 - V3)'''. | ||
==Characteristics of the Brugada syndrome:== | |||
*[[w:Autosomal_dominant|autosomal dominant]] inheritance. If one of both parents are affected, their children have a 50% chance of inheriting the disease. | *[[w:Autosomal_dominant|autosomal dominant]] inheritance. If one of both parents are affected, their children have a 50% chance of inheriting the disease. | ||
*Man are more often symptomatic than women, probably by the influence of sex hormones on cardiac arrhythmias. | *Man are more often symptomatic than women, probably by the influence of sex hormones on cardiac arrhythmias. | ||
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The Brugada brothers were the first to describe the characteristic ECG findings and link them to sudden death. Before that, the characteristic ECG findings, were often mistaken for a [[Right_Ventricle_MI|right ventricle myocardial infarction]] and already in 1953, a publication mentions that the ECG findings were not associated with ischemia as people often expected.<cite>osher</cite> | The Brugada brothers were the first to describe the characteristic ECG findings and link them to sudden death. Before that, the characteristic ECG findings, were often mistaken for a [[Right_Ventricle_MI|right ventricle myocardial infarction]] and already in 1953, a publication mentions that the ECG findings were not associated with ischemia as people often expected.<cite>osher</cite> | ||
==Diagnosis and treatment== | |||
*Patients who are symptomatic (syncope, ventricular tachycardias or survivors of sudden cardiac death) have a mortality risk of up to 10% per year. In these patients an [[:w:nl:Internal_Cardiac_Defibrillator|ICD]] should be implanted. | *Patients who are symptomatic (syncope, ventricular tachycardias or survivors of sudden cardiac death) have a mortality risk of up to 10% per year. In these patients an [[:w:nl:Internal_Cardiac_Defibrillator|ICD]] should be implanted. | ||
*Some groups advice an electrofysiologic investigation for risk assessment in Brugada patients,<cite>brug2</cite><cite>brug3</cite> but others could not reproduce the predicive value of these tests,<cite>priori</cite><cite>eckhardt</cite> so this is still controversial. | *Some groups advice an electrofysiologic investigation for risk assessment in Brugada patients,<cite>brug2</cite><cite>brug3</cite> but others could not reproduce the predicive value of these tests,<cite>priori</cite><cite>eckhardt</cite> so this is still controversial. | ||
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For a full list of the diagnostic criteria, see <cite>Wilde</cite> | For a full list of the diagnostic criteria, see <cite>Wilde</cite> | ||
==Electrocardiographic criteria== | |||
*type 1 | |||
*type 2 | |||
<gallery examples of type I> | |||
</gallery> | |||
==External links== | ==External links== | ||