Conduction

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The PQ interval

The PR duration depends on the conduction velocity in the atria, AV node, His bundle, bundle branches and Purkinje fibers.

The PQ interval starts at the beginning of the atrial contraction and ends at the beginning of the ventricular contraction.

The PQ interval (sometimes referred to as the PR interval as a Q wave is not always present) indicates how fast the action potential is transmitted through the AV node (atrioventricular) from the atria to the ventricles. Measurement should start at the beginning of the P wave to the beginning of the QRS segment.

The normal PQ interval is between 0.12 and 0.20 seconds.

A prolonged PQ interval is a sign of a degradation of the conduction system, increased vagal tone (Bezold-Jarisch reflex), or it can be pharmacologically induced.

This is called 1st, 2nd or 3rd degree AV block.

A short PQ interval can be seen in the WPW syndrome in which a faster connection exists between the atria and the ventricles.

The QRS duration

The QRS duration indicates how fast the ventricles depolarize. The normal QRS is < 0.10 seconds

The ventricles depolarize normally within 0.10 seconds. When this is longer than 110 miliseconds[1], this is a conduction delay. Possible causes of a QRS duration > 110 miliseconds include:

For the diagnosis of LBBB or RBBB QRS duration must be >120 ms.

The QT interval

The QT interval start at the onset of the Q wave and ends where the tangent line for the steepest part of the T wave intersects with the baseline of the ECG. Click on the image for a larger image

The normal QTc interval The QT interval indicates how fast the ventricles are repolarized and how fast they are ready for a new heart cycle.

The normal value for QTc(orrected) is: below 450ms for men and below 460ms for women. [2]

If QTc is < 340ms short QT syndrome can be considered.

The QT interval comprises the QRS-complex, the ST-segment, and the T-wave. One difficultly of QT interpretation is that the QT interval gets shorter if the heart rate increases. This can be solved by correcting the QT time for heart rate using the Bazett formula:

Thus at a heart rate of 60 bpm, the RR interval is 1 second and the QTc equals QT/1. The QTc calculator can be used to easily calculate QTc from the QT and the heart rate or RR interval.

On modern ECG machines, the QTc is given. However, the machines are not always capable in the correct determination of the end of the T wave. Therefore, it is important to check the QT time manually.

Dr Surawicz, founder of the tangent method, still active in November 2006, at age 89.

Although QT prolongation is potentially lethal, measurement of the QT interval by physicians is poor as different definitions of the end of the T wave exist.[3] Most QT experts define the end of the T wave as the intersection of the steepest tangent line from the end of the T-wave with the base line of the ECG.[4] This leads to the following stepwise approach:

Stepwise approach to correct measurement of the QT interval
Use lead II. Use lead V5 alternatively if lead II cannot be read. Draw a line through the baseline (preferably the PR segment) Draw a tangent against the steepest part of the end of the T wave. If the T wave has two positive humps, the tallest hump should be picked. If the T wave is biphasic, the end of the tallest wave should be picked. The QT interval starts at the beginning of the QRS interval and ends where the tangent and baseline cross. If the QRS duration exceeds 120ms the amount surpassing 120ms should be deducted from the QT interval (i.e. QT=QT-(QRS width-120ms) ) Calculate QTc according to Bazett: . You can use the QTc calculator for this.

In a (serious) prolonged QT time, it takes longer for the myocardial cells to be ready for a new cardiac cycle. There is a possibility that some cells are not yet repolarized, but that a new cardiac cycle is already initiated. These cells are at risk for uncontrolled depolarization and induce Torsade de Pointes and subsequent Ventricular Fibrillation.

Causes of QT prolongation
The QT interval is prolonged in congenital long QT syndrome, but QT prolongation can also occur as a consequence of (a.o.): medication (anti-arrhythmics, tricyclic antidepressants, phenothiazedes, for a complete list look on Torsades.org electrolyte imbalances ischemia. QT prolongation is often treated with beta blockers.

If the QT segment is abnormal, it can be difficult to define the end of the T wave. Below are a number of examples that suggest how QT should be measured in these patients.

How to measure QT if the QT segement is abnormal

The T wave is broad, but the tangent crosses the baseline before the T wave joins the baseline. The QT interval would be overestimated when this last definition of the end of the T wave would be used.	The ECG does not meet the baseline after the end of the T wave. Still, the crossing of the tangent and baseline should be used for measurements.	A bifasic T wave. The tangent to the 'hump' with the largest amplitude is chosen. This can change from beat to beat, making it more important to average several measurements.

References

All Medline abstracts: PubMed | HubMed